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THC Material Safety Data Sheet

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*--*  11-15-93  -  11:58:47  *--*
1                                                  OHS23005     PAGE 001 OF 006
                           MATERIAL SAFETY DATA SHEET
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 OCCUPATIONAL HEALTH SERVICES, INC.            FOR EMERGENCY SOURCE INFORMATION
 11 WEST 42ND STREET, 12TH FLOOR               CONTACT: 1-615-366-2000
 NEW YORK, NEW YORK 10036
 1-800-445-MSDS  (1-800-445-6737) OR
 1-212-789-3535
 ------------------------------------------------------------------------------
                            SUBSTANCE IDENTIFICATION
                                                    CAS NUMBER: 1972-08-3
                                                    RTECS NUMBER: HP8225000
 SUBSTANCE: TETRAHYDROCANNABINOL
 TRADE NAMES/SYNONYMS:
   6H-DIBENZO(B,D)PYRAN-1-OL, 6A,7,8,10A-TETRAHYDRO-6,6,9-TRIMETHYL-3-
   PENTYL-, (6A(R)-TRANS)-;
   (6A(R)-TRANS)-6A,7,8,10A-TETRAHYDRO-6,6,9-TRIMETHYL-3-PENTYL-6H-
   DIBENZO(B,D)PYRAN-1-OL;
   CANNABINOL, DELTA-1-TETRAHYDRO-; (L)-DELTA-1-TETRAHYDROCANNABINOL;
   TRANS-DELTA-9-TETRAHYDROCANNABINOL; DELTA-1-TETRAHYDROCANNABINOL;
   DELTA-9-TETRAHYDROCANNABINOL; THC; DELTA-1-THC; DELTA-9-THC; C21H30O2;
   OHS23005
 CHEMICAL FAMILY:
 POLYCYCLIC, HETERO
 MOLECULAR FORMULA: C21-H30-O2
 MOLECULAR WEIGHT: 314.45
 CERCLA RATINGS (SCALE 0-3):  HEALTH=3  FIRE=1  REACTIVITY=0  PERSISTENCE=1
 NFPA RATINGS (SCALE 0-4):  HEALTH=3  FIRE=1  REACTIVITY=0
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                           COMPONENTS AND CONTAMINANTS
 COMPONENT: TETRAHYDROCANNABINOL                            PERCENT: 100.0
            CAS# 1972-08-3
 OTHER CONTAMINANTS: NONE
 EXPOSURE LIMITS:
   NO OCCUPATIONAL EXPOSURE LIMITS ESTABLISHED BY OSHA, ACGIH, OR NIOSH.
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                                  PHYSICAL DATA
 DESCRIPTION: SOLID.    BOILING POINT: 392 F (200 C) @ 0.02 MMHG
 MELTING POINT: NOT AVAILABLE    SPECIFIC GRAVITY: NOT AVAILABLE
 SOLUBILITY IN WATER: NOT AVAILABLE
 SOLVENT SOLUBILITY: SOLUBLE IN ETHANOL.
1                                                  OHS23005     PAGE 002 OF 006
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                             FIRE AND EXPLOSION DATA
 FIRE AND EXPLOSION HAZARD:
 SLIGHT FIRE HAZARD WHEN EXPOSED TO HEAT OR FLAME.
 FIREFIGHTING MEDIA:
 DRY CHEMICAL, CARBON DIOXIDE, WATER SPRAY OR REGULAR FOAM
 (1990 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.5).
 FOR LARGER FIRES, USE WATER SPRAY, FOG OR REGULAR FOAM
 (1990 EMERGENCY RESPONSE GUIDEBOOK, DOT P 5800.5).
 FIREFIGHTING:
 MOVE CONTAINER FROM FIRE AREA IF YOU CAN DO IT WITHOUT RISK (1990 EMERGENCY
 RESPONSE GUIDEBOOK, DOT P 5800.5, GUIDE PAGE 53).
 EXTINGUISH USING AGENT SUITABLE FOR TYPE OF SURROUNDING FIRE. AVOID BREATHING
 VAPORS AND DUSTS. KEEP UPWIND.
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                                    TOXICITY
 TETRAHYDROCANNABINOL:
 TOXICITY DATA: 666 MG/KG ORAL-RAT LD50; 482 MG/KG ORAL-MOUSE LD50; 525 MG/KG
   ORAL-DOG LDLO; 29 MG/KG INTRAVENOUS-RAT LD50; 42 MG/KG INTRAVENOUS-MOUSE
   LD50; 128 MG/KG INTRAVENOUS-MONKEY LDLO; 373 MG/KG INTRAPERITONEAL-RAT
   LD50; 168 MG/KG INTRAPERITONEAL-MOUSE LD50; REPRODUCTIVE EFFECTS DATA
   (RTECS); MUTAGENIC DATA (RTECS); TUMORIGENIC DATA (RTECS).
 CARCINOGEN STATUS: NONE.
 ACUTE TOXICITY LEVEL: MODERATELY TOXIC BY INGESTION.
 TARGET EFFECTS: CENTRAL NERVOUS SYSTEM DEPRESSANT. POISONING MAY ALSO AFFECT
   THE RESPIRATORY, CARDIOVASCULAR AND IMMUNE SYSTEMS.
 ADDITIONAL DATA: THE USE OF ALCOHOLIC BEVERAGES MAY ENHANCE THE TOXIC EFFECTS.
   POISONING MAY IMPAIR THE PERFORMANCE OF TASKS REQUIRING ALERTNESS.
   INTERACTIONS WITH MEDICATIONS HAVE BEEN REPORTED.
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                          HEALTH EFFECTS AND FIRST AID
 INHALATION:
 TETRAHYDROCANNABINOL:
 NARCOTIC.
   ACUTE EXPOSURE- SINCE TETRAHYDROCANNABINOL IS AN ACTIVE INGREDIENT IN
     MARIJUANA, THE TOXIC EFFECTS WILL BE SIMILAR TO THOSE OF MARIJUANA.
     INHALATION OF MARIJUANA SMOKE MAY IRRITATE MUCOUS MEMBRANES CAUSING
     DRYNESS, HOARSENESS AND BRONCHODILATION. RHINITIS, PHARYNGITIS AND ASTHMA
     MAY ALSO OCCUR ACUTELY, BUT ARE MORE COMMON AFTER CHRONIC EXPOSURE.
     SYSTEMIC EFFECTS MAY OCCUR AS DETAILED IN ACUTE INGESTION.
   CHRONIC EXPOSURE- SNIFFING MARIJUANA MAY CAUSE AN ULCERATED OR PERFORATED
     NASAL SEPTUM. REPEATED SMOKING MAY RESULT IN COUGH, LARYNGITIS,
     BRONCHITIS, OTHER RESPIRATORY EFFECTS AS IN ACUTE INHALATION AND
     PULMONARY FUNCTION IMPAIRMENT. LONG-TERM USE BY HUMANS AND EXPERIMENTAL
     ANIMALS HAS LEAD TO SQUAMOUS METAPLASIA OF THE TRACHEAL MUCOSA. SYSTEMIC
     EFFECTS MAY OCCUR AS DETAILED IN CHRONIC INGESTION. REGULAR CHRONIC USE
     MAY RESULT IN REPRODUCTIVE EFFECTS IN MALES INCLUDING DECREASED TESTICULAR
1                                                  OHS23005     PAGE 003 OF 006
     SIZE, TESTOSTERONE LEVELS, SPERM COUNT AND MOTILITY AND ABNORMALITIES
     IN SPERM. GYNECOMASTIA MAY DEVELOP WITH HEAVY USE. FEMALES MAY EXPERIENCE
     A HIGH FREQUENCY OF ABNORMAL PERIODS, LESS OVULATION AND DECREASED
     PROLACTIN LEVELS. REPRODUCTIVE EFFECTS HAVE ALSO BEEN REPORTED IN
     ANIMALS.
 FIRST AID- REMOVE FROM EXPOSURE AREA TO FRESH AIR IMMEDIATELY. IF BREATHING
   HAS STOPPED, PERFORM ARTIFICIAL RESPIRATION. KEEP PERSON WARM AND AT REST.
   TREAT SYMPTOMATICALLY AND SUPPORTIVELY. GET MEDICAL ATTENTION IMMEDIATELY.
 SKIN CONTACT:
 TETRAHYDROCANNABINOL:
   ACUTE EXPOSURE- NO DATA AVAILABLE.
   CHRONIC EXPOSURE- APPLICATION OF "TAR CANNABIS" RESIDUALS TO ANIMAL SKIN
     RESULTED IN TUMOR PRODUCTION.
 FIRST AID- REMOVE CONTAMINATED CLOTHING AND SHOES IMMEDIATELY. WASH AFFECTED
   AREA WITH SOAP OR MILD DETERGENT AND LARGE AMOUNTS OF WATER UNTIL NO
   EVIDENCE OF CHEMICAL REMAINS (APPROXIMATELY 15-20 MINUTES). GET MEDICAL
   ATTENTION IMMEDIATELY.
 EYE CONTACT:
 TETRAHYDROCANNABINOL:
   ACUTE EXPOSURE- SINCE TETRAHYDROCANNABINOL IS AN ACTIVE INGREDIENT IN
     MARIJUANA, THE TOXIC EFFECTS WILL BE SIMILAR TO THOSE OF MARIJUANA.
     SYSTEMIC ADMINISTRATION OF MARIJUANA MAY CAUSE PURPLE-YELLOW VISION,
     HYPEREMIA OF THE CONJUNCTIVA, PUPIL DILATION, SLOW REACTION TO LIGHT AND
     DIPLOPIA.
   CHRONIC EXPOSURE- NO DATA AVAILABLE.
 FIRST AID- WASH EYES IMMEDIATELY WITH LARGE AMOUNTS OF WATER OR NORMAL SALINE,
   OCCASIONALLY LIFTING UPPER AND LOWER LIDS, UNTIL NO EVIDENCE OF CHEMICAL
   REMAINS (APPROXIMATELY 15-20 MINUTES). GET MEDICAL ATTENTION IMMEDIATELY.
 INGESTION:
 TETRAHYDROCANNABINOL:
 NARCOTIC.
   ACUTE EXPOSURE- SINCE TETRAHYCROCANNABINOL IS AN ACTIVE INGREDIENT IN
     MARIJUANA, THE TOXIC EFFECTS WILL BE SIMILAR TO THOSE OF MARIJUANA.
     INGESTION OF LOW TO MODERATE AMOUNTS OF MARIJUANA MAY CAUSE RELAXATION,
     EUPHORIA, AN ALTERED TIME AND SPACE PERCEPTION, VIVID OLFACTORY, AUDITORY
     AND VISUAL SENSES, DISORIENTATION, AND SLEEP, VISUAL AND BODY IMAGE
     DISTURBANCES. INFORMATION LEARNED WHILE INTOXICATED MAY BE POORLY
     RECALLED. DIFFICULTY WITH COGNITIVE FUNCTIONS SUCH AS SPEECH AND
     ORGANIZATION OF THOUGHTS MAY BE ASSOCIATED WITH IMPAIRED SHORT TERM
     MEMORY. PSYCHOMOTOR PERFORMANCES MAY ALSO BE IMPAIRED. OTHER EFFECTS MAY
     INCLUDE DRY MOUTH AND THROAT, HEADACHE, NAUSEA, VOMITING, WEAKNESS,
     RESTLESSNESS, TINNITUS, APPETITE STIMULATION POSSIBLY DUE TO
     HYPOGLYCEMIA, TREMOR, DELIRIUM, JOCULARITY, STUPOR, ATAXIA, DEPRESSION,
     AGGRESSIVENESS AND PARESTHESIAS. RESIDUAL SEDATION MAY PERSIST THE
     FOLLOWING DAY. POSSIBLE CARDIOVASCULAR EFFECTS INCLUDE HYPERTENSION OR
     HYPOTENSION, SINUS TACHYCARDIA AND PREMATURE VENTRICULAR CONTRACTIONS.
     LARGE DOSES MAY LEAD TO DEPERSONALIZATION, LOSS OF INSIGHT, ANXIETY,
     PARANOIA, ACUTE PSYCHOSIS AND OBSESSIONAL THOUGHT CHARACTERIZED BY
     DELUSIONS, HALLUCINATIONS, ILLUSIONS AND BIZARRE BEHAVIOR. DEATH IS RARE
     BUT MAY RESULT FROM RESPIRATORY ARREST OR CARDIOVASCULAR COLLAPSE. EFFECTS
     ON SPERMATOGENESIS IN MICE HAVE BEEN REPORTED FROM ADMINISTRATION OF A
     SINGLE DOSE.
1                                                  OHS23005     PAGE 004 OF 006
   CHRONIC EXPOSURE- REPEATED INGESTION MAY RESULT IN A LOWERING OF THE
     SENSORY THRESHOLD, APATHY, DULLNESS, ANXIETY, PANIC, AGGRESSIVENESS,
     DISORIENTATION, CONFUSION, CLOUDING OF MENTAL PROCESSES WITH IMPAIRED
     JUDGEMENT AND MEMORY, LOSS OF PERSPECTIVE, REDUCED MOTIVATION AND
     ACUTE INSECURITY. WEIGHT GAIN MAY OCCUR DUE TO APPETITE STIMULATION.
     FLASHBACKS HAVE BEEN REPORTED. REDUCED T-LYMPHOCYTES AND IMPAIRED
     CELL-MEDIATED IMMUNITY MAY OCCUR. TOLERANCE AND PSYCHOLOGICAL AND PHYSICAL
     DEPENDENCE MAY DEVELOP WITH HEAVY PROLONGED USE. SYMPTOMS OF WITHDRAWAL
     MAY OCCUR. MAY BE EXCRETED IN BREAST MILK. REPRODUCTIVE EFFECTS HAVE BEEN
     REPORTED IN ANIMALS.
 FIRST AID- TREAT SYMPTOMATICALLY AND SUPPORTIVELY. GET MEDICAL ATTENTION
   IMMEDIATELY. IF VOMITING OCCURS, KEEP HEAD LOWER THAN HIPS TO PREVENT
   ASPIRATION.
 ANTIDOTE:
 NO SPECIFIC ANTIDOTE. TREAT SYMPTOMATICALLY AND SUPPORTIVELY.
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                                   REACTIVITY
 REACTIVITY:
 STABLE UNDER NORMAL TEMPERATURES AND PRESSURES.
 INCOMPATIBILITIES:
 TETRAHYDROCANNABINOL:
   OXIDIZERS (STRONG): FIRE AND EXPLOSION HAZARD.
 DECOMPOSITION:
 THERMAL DECOMPOSITION MAY RELEASE ACRID SMOKE AND IRRITATING FUMES.
 POLYMERIZATION:
 HAZARDOUS POLYMERIZATION HAS NOT BEEN REPORTED TO OCCUR UNDER NORMAL
 TEMPERATURES AND PRESSURES.
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                              STORAGE AND DISPOSAL
 OBSERVE ALL FEDERAL, STATE AND LOCAL REGULATIONS WHEN STORING OR DISPOSING
 OF THIS SUBSTANCE. FOR ASSISTANCE, CONTACT THE DISTRICT DIRECTOR OF THE
 ENVIRONMENTAL PROTECTION AGENCY.
                                  **STORAGE**
 STORAGE OF CONTROLLED SUBSTANCES MUST COMPLY WITH APPLICABLE SECURITY
 REQUIRMENTS IN 21 CFR 1301.71, 1301.72, 1301.73, 1301.74, 1301.75 AND 1301.76.
 STORE AWAY FROM INCOMPATIBLE SUBSTANCES.
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                              CONDITIONS TO AVOID
 MAY BURN BUT DOES NOT IGNITE READILY. PREVENT DISPERSION OF DUST IN AIR. DO
 NOT ALLOW SPILLED MATERIAL TO CONTAMINATE WATER SOURCES.
1                                                  OHS23005     PAGE 005 OF 006
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                            SPILL AND LEAK PROCEDURES
 OCCUPATIONAL SPILL:
 DO NOT TOUCH SPILLED MATERIAL. STOP LEAK IF YOU CAN DO IT WITHOUT RISK. FOR
 SMALL SPILLS, TAKE UP WITH SAND OR OTHER ABSORBENT MATERIAL AND PLACE INTO
 CONTAINERS FOR LATER DISPOSAL. FOR SMALL DRY SPILLS, WITH A CLEAN SHOVEL
 PLACE MATERIAL INTO CLEAN, DRY CONTAINER AND COVER. MOVE CONTAINERS FROM
 SPILL AREA. FOR LARGER SPILLS, DIKE FAR AHEAD OF SPILL FOR LATER DISPOSAL.
 KEEP UNNECESSARY PEOPLE AWAY. ISOLATE HAZARD AREA AND DENY ENTRY.
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                              PROTECTIVE EQUIPMENT
 VENTILATION:
 PROVIDE LOCAL EXHAUST OR PROCESS ENCLOSURE VENTILATION SYSTEM.
 RESPIRATOR:
 THE FOLLOWING RESPIRATORS ARE RECOMMENDED BASED ON INFORMATION FOUND IN THE
   PHYSICAL DATA, TOXICITY AND HEALTH EFFECTS SECTIONS. THEY ARE RANKED IN
   ORDER FROM MINIMUM TO MAXIMUM RESPIRATORY PROTECTION.
 THE SPECIFIC RESPIRATOR SELECTED MUST BE BASED ON CONTAMINATION LEVELS FOUND
   IN THE WORK PLACE, MUST BE BASED ON THE SPECIFIC OPERATION, MUST NOT EXCEED
   THE WORKING LIMITS OF THE RESPIRATOR AND MUST BE JOINTLY APPROVED BY THE
   NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH AND THE MINE SAFETY
   AND HEALTH ADMINISTRATION (NIOSH-MSHA).
   ANY DUST AND MIST RESPIRATOR WITH A FULL FACEPIECE.
   ANY AIR-PURIFYING FULL FACEPIECE RESPIRATOR WITH A HIGH-EFFICIENCY
     PARTICULATE FILTER.
   ANY POWERED AIR-PURIFYING RESPIRATOR WITH A TIGHT-FITTING FACEPIECE AND
     HIGH-EFFICIENCY PARTICULATE FILTER.
   ANY TYPE 'C' SUPPLIED-AIR RESPIRATOR WITH A FULL FACEPIECE OPERATED IN
     PRESSURE-DEMAND OR OTHER POSITIVE PRESSURE MODE OR WITH A FULL FACEPIECE,
     HELMET OR HOOD OPERATED IN CONTINUOUS-FLOW MODE.
   ANY SELF-CONTAINED BREATHING APPARATUS WITH A FULL FACEPIECE OPERATED IN
     PRESSURE-DEMAND OR OTHER POSITIVE PRESSURE MODE.
 FOR FIREFIGHTING AND OTHER IMMEDIATELY DANGEROUS TO LIFE OR HEALTH CONDITIONS:
   ANY SELF-CONTAINED BREATHING APPARATUS THAT HAS A FULL FACEPIECE AND IS
     OPERATED IN A PRESSURE-DEMAND OR OTHER POSITIVE-PRESSURE MODE.
   ANY SUPPLIED-AIR RESPIRATOR THAT HAS A FULL FACEPIECE AND IS OPERATED IN A
     PRESSURE-DEMAND OR OTHER POSITIVE-PRESSURE MODE IN COMBINATION WITH AN
     AUXILIARY SELF-CONTAINED BREATHING APPARATUS OPERATED IN PRESSURE-DEMAND
     OR OTHER POSITIVE-PRESSURE MODE.
 CLOTHING:
 EMPLOYEE MUST WEAR APPROPRIATE PROTECTIVE (IMPERVIOUS) CLOTHING AND EQUIPMENT
 TO PREVENT REPEATED OR PROLONGED SKIN CONTACT WITH THIS SUBSTANCE.
1                                                  OHS23005     PAGE 006 OF 006
 GLOVES:
 EMPLOYEE MUST WEAR APPROPRIATE PROTECTIVE GLOVES TO PREVENT CONTACT WITH THIS
 SUBSTANCE.
 EYE PROTECTION:
 EMPLOYEE MUST WEAR SPLASH-PROOF OR DUST-RESISTANT SAFETY GOGGLES TO PREVENT
 EYE CONTACT WITH THIS SUBSTANCE.
 EMERGENCY EYE WASH: WHERE THERE IS ANY POSSIBILITY THAT AN EMPLOYEE'S EYES MAY
 BE EXPOSED TO THIS SUBSTANCE, THE EMPLOYER SHOULD PROVIDE AN EYE WASH
 FOUNTAIN WITHIN THE IMMEDIATE WORK AREA FOR EMERGENCY USE.
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   COPYRIGHT  1992  OCCUPATIONAL HEALTH SERVICES, INC..  ALL RIGHTS RESERVED.
           CREATION DATE: 10/19/88          REVISION DATE: 10/12/92