Listed below are some of the known interactions between Venlafaxine and other chemicals, plants or pharmaceutical medications. This is not a comprehensive list. Substances which are not listed below may still have significant and/or dangerous interaction with Venlafaxine.

SUBSTANCE	RELATIONSHIP	KNOWN ISSUES	SYMPTOMS	REFS
Cannabis	Exp Report Tentative Life-Threatening	Erowid received a report of a man prescribed venlafaxine who experienced tachycardia, arrhythmia, and seizures when he smoked cannabis and then took his normal dose of venlafaxine. Others have reported no such dangerous interaction.	tachycardia, arrhythmia, seizure	Erowid 2003 Erowid 2004 Erowid 2004
Salvia divinorum	Exp Report Tentative Life-Threatening	Erowid received a report of a man prescribed venlafaxine who experienced two seizure-like episodes on the two occasions that they tried to smoke Salvia divinorum.	seizure-like	Submitted via interaction form, Nov 2005, by PR
Amphetamine	Case Report Dangerous	Single case report of a 32 year old man prescribed both amphetamine (5mg x 3 per day) and venlafaxine (150mg x 1 per day) who presented with "marked agitation, anxiety, shivering and tremor."	anxiety, shivering, tremor, serotonin syndrome	Prior FH 2002
Lithium	Case Report Dangerous	Single case report of 50 year old woman prescribed both lithium and venlafaxine who was reported to have experienced serotonin syndrome.	serotonin syndrome	Mekler G 1997
Metoclopramide	Case Report Dangerous	Case report of 32 year old woman prescribed venlafaxine and administered metoclopramide in a hospital after an injury. She "developed movement disorder and a period of unresponsiveness. After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension."	tachycardia, confusion, hypertension, serotonin syndrome	Fisher AA 2002
Phenelzine (MAOI)	Case Report Life-Threatening	Several case reports of potentially dangerous interactions. One case report of 44 year-old woman who accidentally ingested phenelzine with venlafaxine and was admitted to an emergency department with lower extremity tremors and rapid respiration where she was diagnosed with serotonin syndrome. Other case reports involve patients who experienced serotonin syndrome while transitioning from phenelzine to venlafaxine.	anxiety, tremors, rapid respiration, serotonin syndrome	Weiner LA Diamond S 1998
Propafenone	Case Report Dangerous	Single case report of patient treated for bipolar affective disorder in which venlafaxine given with propafenone caused "markedly increased serum levels of venlafaxine correlating with unexpected psychopathological changes."	psychosis	Pfeffer F 2001
Tranylcypromine	Case Report Life-Threatening	One case report of 60 year-old woman who accidentally ingested venlafaxine while on a chronic prescription of tranylcypromine and experienced "altered mental status that progressed to hyperthermia and coma. She recovered quickly and without complications."	hyperthermia, coma	Hodgman MJ 1997
Trimipramine	Case Report Life-Threatening	Single case report of 25 year-old woman on 150mg per day of venlaxine and 100mg per day of trimipramine hospitalized when seizures occured. Both drugs were discontinued and seizures stopped and did not recur.	seizures	Schlienger RG 2000
If you have a negative drug interaction to report, please let us know.