|[3D .mol structure]|
A = hydrogenAnd let's arrange the 5-methoxylated tryptamines in order of increasing mass, and see if there is a pattern apparent as to the quantity or quality of action.
B = methyl
C = ethyl
D = propyl
E = isopropyl
F = butyl
G = s-butyl
A A 5-MeO-T anti-radiation, not a psychedelic ?So, I ask, how could C C be modified to eliminate the vertigo component, maintain the erotic component, perhaps even maintain the psychedelic component, and certainly maintain the orally active property. Clearly, tying them together in the form of a pyrrolidine ring didn't do it. Only one of these listed 5-methoxy of known activity is asymmetric, the methyl isopropyl analogue. It is probably through this device of mixing and comparing, that our answer will be found. Some guide might come from the 5-hydrogen counterparts, more of which have been explored in man. The variations with a constant isopropyl group have been organized in the recipe for EIPT. Here is the rest of the story.
A B 5-MeO-NMT unknown activity ?
B B 5-MeO-DMT, positive, psychedelic, out-of-body, 6-20 mg
B E 5-MeO-MIPT mixed, complex 4-6 mg
C C 5-MeO-DET negative, vertigo, erotic, 2-3 mg
C-- C 5-MeO-pyr-T very negative, amnesia 0.5-2 mg
D D 5-MeO-DPT neutral, balance, good and bad 6-10 mg
E E 5-MeO-DIPT positive, LSD-like psychedelic, 8-12 mg
F F 5-MeO-DBT known compound, unknown activity ?
G G 5-MeO-DSBT unknown compound -
B C MET positive, psychedelic 80-100 mgMy hope is that getting leads from the second list (no substituent at the indolic 5-position) could help guide the choice of asymmetric substituents for the first list (a methoxy group at the 5-position) that would lead to an expected increase in potency but to an unexpected change in quality of action.
B D MPT unknown > 50 mg
B E MIPT mixed, complex 10-25 mg
B F MBT mixed 250-400 mg
B G MSBT unknown ?
C E EIPT mixed 24-40 mg
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