I suffer from clinically diagnosed GAD, Major Depressive Disorder, and PTSD. I have tried many, many, many medications over the years to help. Most don't work at all, or work too well. Some work fine for a while, then stop working after 3 months or so.
My doctor prescribed the mirtazapine at the beginning of the year. It is, thus far, the best medication I have had. It helps with the depression while allowing me to feel a full range of emotions. Taken at bedtime, it also helps me sleep, which is important because I have been a chronic insomnia sufferer.