I researched this drug, which I experience as at least as powerful as any antidepressant I've taken (and there have been many), on several medical sites. All of those sites indicated to me that I should BEGIN with 5mg and ease up to 25- 50mg.
They did mention 'superdosing' at hundreds of mgs, but stated it was extremely dangerous. I was not about to go there.
I have taken DHEA for about a year. I took it once, felt great, but came off it to see if Metformin would work better (in terms of reducing body fat). Immediately I crashed and burned by way of mood and energy. About a week after being off it, I slept for 3 days straight, not having even started the Metformin.
I went back on a whole 25mg--to work upwards from there. Again IMMEDIATELY I felt energetic, hyper, clear minded, like going out and doing things--almost hypomanic. Also I HAVE been able to lose weight while on DHEA, and dieting/exercising like mad, when for years my weight had been 'stuck' no matter how little I ate.