It is possible to test for the presence of LSD in urine, but it is a very difficult and expensive test to run and is very uncommon. Unless there is a particular reason to be looking for it, as in the case of an autopsy...it is extremely unlikely that most people will ever run into this test. It is not one of the SAMHSA-5 standardly tested for in the basic drug test, nor is it included in the extended drug tests. It is not chemically similar to any of the drugs tested for, so should not trigger the tests as another substance.

Beginning in the early 2000's, some parts of the military began testing for LSD. However, the Feb 18, 2008 Army Times reported that the Department of Defense has stopped LSD testing military wide. Reportedly this was because only four positive LSD tests were found out of more than 2 million test conducted over a three year period. A cost-benefit analysis resulted in the military ceasing LSD testing as part of their standard panel. Note that it is possible that non-standard tests are conducted in unique cases. We have been told that the Air Force will court martial airmen on the basis of a single positive test for LSD. If you know anything else about the military's handling of drug tests, let us know.