LSA is a naturally occuring psychedelic chemical with a potency 1/10 to 1/30th that of LSD. It has some similarities in effect to LSD, but is generally considered much less stimulating and can be sedating. Structurally LSA and LSD are
quite similar.
Dosage of LSA is not well established since few have experimented with the pure chemical and recorded their experiences publicly. Hofmann tried an I.M. injection of 500micrograms of LSA and found the effects medium-strong. Hofmann later reports that the active oral dose of LSA at "2 to 5 milligrams".
Dosages for Morning Glory seeds vary over a wide range. Of the 39 morning glory experience reports as of December 2000, the 5 rated with 'strong' intensity describe taking between from 280-525 (rough approximation) seeds, the 'medium' intensity reports vary between 125 and 600 seeds, and the light experiences vary between 25 and 700.
There are a number of confounding factors in trying to interpret the available data including the many different seed sources, the reported variation in potency from the same seed supplier from order to order, and widely varying preparation / extraction techniques. One interesting piece of data is that 4 of the 5 'strong' experiences used no solvent wash as part of the preparation, but many of the other reports do include washing with naptha or other non-polar solvent. This link is tenuous, at best, but may be worth further investigation.
One very experienced Morning Glory seed user has written a
report which suggests that 150-250 seeds would be a minimal dose and with "a strong batch of seeds" 500-1000 seeds would produce a "psychedelic" experience. In private correspondence, this author also described taking 1-2 thousand seeds from weaker batches.
Quotes Regarding Dosage & Effects of LSD / Morning Glory
"Hofmann first established its effect in 1947, 13 years before it was known to be the active principle in ololiuhqui... He showed that the drug was active at doses of 500 micrograms to 1 milligram. No entheogenic effect was noticed by Hofmann after taking 2 milligrams of isoergine, although sedative symptoms similar to ergine inebriation were prominent. Hofmann's description of perceiving the 'unreality and complete meaninglessness of the outside world' after taking 2 millgrams of isoergine (Hofmann 1963a), however, sounds like the paradoxical depressent effect experienced commonly with the threshold doses of psilocybine and other entheogens and it is possible that isoergine is entheogenic at higher doses." (Ott
Pharmacotheon 1993, pg. 128)
"Experienced users of entheogenic morning glory seeds usually start with low doses, later working up to higher amounts if a more intense effect is desired. The wise user will begin with no more than 4 or 5 seeds of Argyreia nervosa, or no more than 20-25 seeds of Ipomoea violacea. Seeds of Turbina corumbosa are about one fifth as potent as the seeds of Ipomoea violacea. In Mexico, I have seen doses of the true ololiuhqui seeds, Turbina corymbosa, measured as the quantity of seeds which will fill a bottle cap, and Wasson also reported this volumetric dosage aid in the Sierra Mazateca (Wasson 1963). Osmond found 60-100 seeds Turbina corymbosa seeds to be an active dose, though he chewed and ingested the whole seeds, rather than making a cold water infusion of ground seeds (Osmond 1955; see Note 11).
The seeds are not ingested whole--they are not active in this form (Kinross-Wright 1959; B.P. Reko 1934). They are ground to a fine powder, which is then steeped for several hours in cold water, after which the solid matter is filtered off and discarded. The liquid is then drunk neat or with juice for flavoring." (Ott
Pharmacotheon 1993, pg. 140)
"[Ergine] is an active compound and has been established as a major component in morning glory seeds. It was assayed for human activity, by Albert Hofmann in self trials back in 1947, well before this was known to be a natural compound. An I.M. administration of a 500 microgram dose led to a tired, dream state with an inability to maintain clear thoughts. After a short period of sleep, the effects were gone and normal baseline was recovered within 5 hours." (Shulgin,
TIHKAL, 1997, page 497)
"The slight difference in chemical structure between the ololiuqui constituents and LSD is very significant with regard to hallucinogenic acitivity. The effective oral dose in man of LSD is 0.05 mg [which] is thus about 50 to 100 times more active than lysergic acid amide, which is active in doses of 2 to 5 mg. Furthermore there is not only a quantitative difference between the principles of
Ipomoea violacea and
Turbina corymbosa and LSD; there is likewise a qualitative one, LSD being a very specific hallucinogen, whereas the psychic effects of lysergic acid amide and the total alkaloids of these two plants are characterized by a pronounced narcotic component (Hofmann, 1968)" (
Botany & Chemistry of Hallucinogens, Shultes & Hofmann, 1980)
Approximate Number of Morning Glory Seeds by Exp. Report Intensity Rating
| Strong | 300 no naptha, 280 no naptha, 400 no naptha, 440 with naptha,
15g (525*) no naptha, 350 no naptha |
| Medium | 475 no naptha, 240, 400, 450, 125 naptha, 500, 300, 315, 154, 315,
110, 350, 315, 245, 470, 315 no naptha |
| Light | 140, 150, 200, 250, 350 naptha, 38, 25, 48, 500 no naptha, 125, 250,
200, 700 starting fluid (heptain, diethyl ether, hexane), 262 no naptha |
| | * - using 35 seeds per gram for rough estimates |
Every individual reacts differently to every chemical.
Know your Body - Know your Mind - Know your Substance - Know your Source.
Erowid's dosage information is a summary of data gathered from users, research, and other
resources and should not be construed as recommendations. Individuals can respond
differently to the same dosage. What is safe for one can be deadly for another.
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