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Caffeine Material Safety Data Sheet

                 University of California  -  MSDS System              PAGE    1
                                                                        06/27/97
Source of MSDS: FISHER SCIENTIFIC CORPORATION
                          MATERIAL SAFETY DATA SHEET
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FISHER SCIENTIFIC                         EMERGENCY NUMBER USA: (201) 796-7100
CHEMICAL DIVISION                         CHEMTREC ASSISTANCE: (800) 424-9300
1 REAGENT LANE                            CANADA: (613) 226-8874
FAIR LAWN, NJ 07410
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                           SUBSTANCE IDENTIFICATION
                                                   CAS NUMBER: 58-08-2
                                                   RTECS NUMBER: EV6475000
SUBSTANCE: **CAFFEINE**
TRADE NAMES/SYNONYMS:
  1H-PURINE-2,6-DIONE, 3,7-DIHYDRO-1,3,7-TRIMETHYL-;
  1H-PURINE-2,6-DIONE,3,7-DIHYDRO-1,3,7-TRIMETHYL-, THEINE;
  3,7-DIHYDRO-1,3,7-TRIMETHYL-1H-PURINE-2,6-DIONE;
  1,3,7-TRIMETHYL-2,6-DIOXOPURINE; 1,3,7-TRIMETHYLXANTHINE; TRIMETHYLXANTHINE;
  7-METHYLTHEOPHYLLINE; METHYLTHEOBROMINE; ALERT-PEP; CAFEINA; CAFFEIN;
  CATIPEL; GUARANINE; KOFFEIN; MATEINA; NO-DOZ; REFRESH'N; STIM; THEIN;
  C8H10N4O2;
CHEMICAL FAMILY:
Alkaloid
MOLECULAR FORMULA: C8-H10-N4-O2
MOLECULAR WEIGHT: 194.19
CERCLA RATINGS (SCALE 0-3):  HEALTH=3  FIRE=1  REACTIVITY=0  PERSISTENCE=1
NFPA RATINGS (SCALE 0-4):  HEALTH=2  FIRE=1  REACTIVITY=0
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                          COMPONENTS AND CONTAMINANTS
COMPONENT: CAFFEINE                                        PERCENT: 100.0
           CAS# 58-08-2
OTHER CONTAMINANTS: NONE.
EXPOSURE LIMITS:
No occupational exposure limits established by OSHA, ACGIH, or NIOSH.
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                                 PHYSICAL DATA
DESCRIPTION: Odorless, white, fleecy masses, glistening needles or powder with
a bitter taste.    BOILING POINT: 352 F (178 C) (sublimes)
MELTING POINT: 460 F (238 C)    SPECIFIC GRAVITY: 1.2    VOLATILITY: 0.5%
                 University of California  -  MSDS System              PAGE    2
                                                                        06/27/97
VAPOR PRESSURE: 760 mmHg @ 178 C    PH: 6.9 (1% solution)
SOLUBILITY IN WATER: 2.17%    VAPOR DENSITY: 6.7
SOLVENT SOLUBILITY: Soluble in ethyl acetate, chloroform, pyrimidine,
pyrrole, tetrahydrofuran solution; moderately soluble i alcohol, accetone;
slightly soluble in petroleum ether, ether, benzene.
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                            FIRE AND EXPLOSION DATA
FIRE AND EXPLOSION HAZARD:
Slight fire hazard when exposed to heat or flame.
Dust-air mixtures may ignite or explode.
AUTOIGNITION TEMP.: 1697 F (925 C)
FIREFIGHTING MEDIA:
Dry chemical, carbon dioxide, water spray or regular foam
(1993 Emergency Response Guidebook, RSPA P 5800.6).
For larger fires, use water spray, fog or regular foam
(1993 Emergency Response Guidebook, RSPA P 5800.6).
FIREFIGHTING:
Move container from fire area if you can do it without risk (1993 Emergency
Response Guidebook, RSPA P 5800.6, Guide Page 53).
Extinguish using agent suitable for type of surrounding fire. Avoid breathing
vapors and dusts. Keep upwind.
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                              TRANSPORTATION DATA
U.S. DEPARTMENT OF TRANSPORTATION SHIPPING NAME-ID NUMBER, 49 CFR 172.101:
Poisonous solids, n.o.s.(caffeine)-UN 2811
U.S. DEPARTMENT OF TRANSPORTATION HAZARD CLASS OR DIVISION, 49 CFR 172.101:
6.1 - Poisonous materials
U.S. DEPARTMENT OF TRANSPORTATION PACKING GROUP, 49 CFR 172.101:
PG III
U.S. DEPARTMENT OF TRANSPORTATION LABELING REQUIREMENTS, 49 CFR 172.101
  AND SUBPART E:
Keep away from food
U.S. DEPARTMENT OF TRANSPORTATION PACKAGING AUTHORIZATIONS:
EXCEPTIONS: 49 CFR 173.153
NON-BULK PACKAGING: 49 CFR 173.213
BULK PACKAGING: 49 CFR 173.240
U.S. DEPARTMENT OF TRANSPORTATION QUANTITY LIMITATIONS 49 CFR 172.101:
PASSENGER AIRCRAFT OR RAILCAR: 100 kg
CARGO AIRCRAFT ONLY: 200 kg
                 University of California  -  MSDS System              PAGE    3
                                                                        06/27/97
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                                   TOXICITY
CAFFEINE:
TOXICITY DATA:
  ANHYDROUS: 320 mg/kg oral-child LDLo; 192 mg/kg oral-human LDLo;
    14700 ug/kg oral-infant TDLo; 13 mg/kg oral-man TDLo; 96 mg/kg/1 day
    intermittent oral-woman TDLo; 1 gm/kg oral-woman LDLo; 192 mg/kg oral-rat
    LD50; 127 mg/kg oral-mouse LD50; 224 mg/kg oral-rabbit LD50; 100 mg/kg
    oral-cat LDLo; 140 mg/kg oral-dog LD50; 230 mg/kg oral-guinea pig LD50;
    230 mg/kg oral-hamster LD50; 170 mg/kg subcutaneous-rat LD50; 242 mg/kg
    subcutaneous-mouse LD50; 275 mg/kg subcutaneous-rabbit LDLo; 7 mg/kg
    intravenous-human TDLo; 57 mg/kg intravenous-woman LDLo; 68 mg/kg
    intravenous-infant TDLo; 105 mg/kg intravenous-rat LD50; 62 mg/kg
    intravenous-mouse LD50; 58 mg/kg intravenous-rabbit LD50; 240 mg/kg
    intraperitoneal-rat LD50; mutagenic data (RTECS); reproductive effects
    data (RTECS); tumorigenic data (RTECS).
  MONOHYDRATE: No data available.
CARCINOGEN STATUS: Human Inadequate Evidence, Animal Inadequate Evidence (IARC
  Group-3).
ACUTE TOXICITY LEVEL: Toxic by ingestion.
TARGET EFFECTS: Poisoning may affect the central nervous system and heart.
AT INCREASED RISK FROM EXPOSURE: Persons with glaucoma, duodenal ulcers,
  liver, cardiovascular, renal or psychological disorders.
ADDITIONAL DATA: May cross the placenta. May be excreted in breast milk.
  Alcohol may enhance the toxic effects. Interactions with medications have
  been reported.
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                         HEALTH EFFECTS AND FIRST AID
INHALATION:
CAFFEINE:
  ACUTE EXPOSURE- May irritate the nose and throat and cause coughing and
    chest discomfort. If sufficient quantities are absorbed, may cause
    poisoning as detailed in acute ingestion. No deaths were reported in
    rats exposed to 55 ppm for 4 hours.
  CHRONIC EXPOSURE- If sufficient quantities are absorbed, may cause poisoning
    as detailed in chronic ingestion.
FIRST AID- Remove from exposure area to fresh air immediately. Perform
  artificial respiration if necessary. Keep person warm and at rest. Treat
  symptomatically and supportively. Get medical attention immediately.
SKIN CONTACT:
CAFFEINE:
  ACUTE EXPOSURE- May cause irritation.
  CHRONIC EXPOSURE- No data available.
FIRST AID- Remove contaminated clothing and shoes immediately. Wash with
  soap or mild detergent and large amounts of water until no evidence of
  chemical remains (at least 15-20 minutes). Get medical attention
  immediately.
EYE CONTACT:
                 University of California  -  MSDS System              PAGE    4
                                                                        06/27/97
CAFFEINE:
  ACUTE EXPOSURE- May cause irritation.
  CHRONIC EXPOSURE- No data available.
FIRST AID- Wash eyes immediately with large amounts of water or normal saline,
  occasionally lifting upper and lower lids, until no evidence of chemical
  remains (at least 15-20 minutes). Get medical attention immediately.
INGESTION:
CAFFEINE:
TOXIC.
  ACUTE EXPOSURE- Low concentrations may cause a small decrease in heart rate.
    Ingestion of large amounts may result in headache, lightheadedness,
    dizziness, chills, fever, excitement, restlessness, nervousness, insomnia,
    mild delirium, hallucinations, tinnitus, constricted pupils, decreased
    visual fields, amblyopia, diplopia, photophobia, and scintillating
    scotoma. Neurologic symptoms may persist for several days. May cause
    gastrointestinal irritation, nausea, vomiting, stimulation of gastric
    acid secretion, anorexia, hematemesis, abdominal cramps, diarrhea, and
    diuresis followed by oliguria and dehydration. Other effects may include
    alternating states of consciousness and muscle twitching, tremors,
    hyperesthesia, hypertonicity or hypotonicity, trismus, opisthotonus and
    convulsions. Slight increase in basal metabolic rate, metabolic acidosis,
    ketonuria, glycosuria, hyperglycemia, hypokalemia and rhabdomyolysis
    have been reported. Other effects may include dyspnea, tachypnea, chest
    tightness, palpitations, increase in systolic blood pressure, and
    arrhythmias including tachycardia and extrasystoles. Seizures generally
    precede death.
  CHRONIC EXPOSURE- In addition to the effects detailed in acute exposure,
    agitation, disturbed sleep, caffeine-induced psychosis, heartburn and
    hyperventilation may occur. Low grade fever and elevated plasma free
    fatty acid have been reported. Respiratory failure and cardiopulmonary
    arrest may occur. Prolonged use of high doses may result in tolerence,
    physical and psychological dependence. Symptoms of withdrawal may occur
    following abrupt cessation. Use of caffeine by pregnant women has been
    associated with increased incidences of spontaneous abortion, breech
    presentations, stillbirth, premature delivery, low birth weight,
    developmental abnormalities of the craniofacial and musculoskeletal
    systems and babies with decreased activity and decreased muscle tone.
    Other reproductive effects have been reported in animals. As evaluated by
    RTECS, administration to mice resulted in a statistically significant
    increase in the incidence of carcinogenic tumors of the skin and
    appendages.
FIRST AID- If the person is conscious and not convulsing, induce emesis by
  giving syrup of ipecac followed by water or by gastric lavage using
  activated charcoal whether or not vomiting has occurred. (If vomiting
  occurs keep the head below the hips to prevent aspiration). (Dreisbach,
  Handbook of Poisoning, 12th Ed.). Treat symptomatically and supportively.
  Gastric lavage should be performed by qualified medical personnel. Get
  medical attention immediately.
ANTIDOTE:
No specific antidote. Treat symptomatically and supportively.
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                 University of California  -  MSDS System              PAGE    5
                                                                        06/27/97
                                  REACTIVITY
REACTIVITY:
Stable under normal temperatures and pressures.
INCOMPATIBILITIES:
CAFFEINE:
  ACIDS (STRONG): Incompatible.
  BASES (STRONG): Incompatible.
  CHLORINE WATER: Incompatible.
  OXIDIZERS (STRONG): Fire and explosion hazard.
DECOMPOSITION:
Thermal decomposition products may include toxic oxides of carbon and
nitrogen.
POLYMERIZATION:
Hazardous polymerization has not been reported to occur under normal
temperatures and pressures.
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                             STORAGE AND DISPOSAL
Observe all federal, state and local regulations when storing or disposing
of this substance.
                                 **Storage**
Store in a tightly closed container.
Store away from incompatible substances.
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                             CONDITIONS TO AVOID
May burn but does not ignite readily. Prevent dispersion of dust in air. Do
not allow spilled material to contaminate water sources.
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                           SPILL AND LEAK PROCEDURES
OCCUPATIONAL SPILL:
Do not touch spilled material. Stop leak if you can do it without risk. For
small spills, take up with sand or other absorbent material and place into
containers for later disposal. For small dry spills, with a clean shovel
place material into clean, dry container and cover. Move containers from
spill area. For larger spills, dike far ahead of spill for later disposal.
Keep unnecessary people away. Isolate hazard area and deny entry.
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                             PROTECTIVE EQUIPMENT
VENTILATION:
Provide local exhaust or process enclosure ventilation. Ventilation equipment
should be explosion-proof if explosive concentrations of dust, vapor or fume
                 University of California  -  MSDS System              PAGE    6
                                                                        06/27/97
are present.
RESPIRATOR:
The following respirators are recommended based on information found in the
  physical data, toxicity and health effects sections. They are ranked in
  order from minimum to maximum respiratory protection.
The specific respirator selected must be based on contamination levels found
  in the work place, must be based on the specific operation, must not exceed
  the working limits of the respirator and must be jointly approved by the
  National Institute for Occupational Safety and Health and the Mine Safety
  and Health Administration (NIOSH-MSHA).
  Any dust and mist respirator.
  Any air-purifying respirator with a high-efficiency particulate filter.
  Any powered air-purifying respirator with a dust and mist filter.
  Any powered air-purifying respirator with a high-efficiency particulate
    filter.
  Any type 'C' supplied-air respirator operated in the pressure-demand or
    other positive pressure or continuous-flow mode.
  Any self-contained breathing apparatus.
FOR FIREFIGHTING AND OTHER IMMEDIATELY DANGEROUS TO LIFE OR HEALTH CONDITIONS:
  Any self-contained breathing apparatus that has a full facepiece and is
    operated in a pressure-demand or other positive-pressure mode.
  Any supplied-air respirator that has a full facepiece and is operated in a
    pressure-demand or other positive-pressure mode in combination with an
    auxiliary self-contained breathing apparatus operated in pressure-demand
    or other positive-pressure mode.
CLOTHING:
Employee must wear appropriate protective (impervious) clothing and equipment
to prevent any possibility of skin contact with this substance.
GLOVES:
Employee must wear appropriate protective gloves to prevent contact with this
substance.
EYE PROTECTION:
Employee must wear splash-proof or dust-resistant safety goggles and a
faceshield to prevent contact with this substance.
Emergency wash facilities:
Where there is any possibility that an employee's eyes and/or skin may be
exposed to this substance, the employer should provide an eye wash fountain
and quick drench shower within the immediate work area for emergency use.
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                 University of California  -  MSDS System              PAGE    7
                                                                        06/27/97
  COPYRIGHT  1984-1995  MDL INFORMATION SYSTEMS, INC.  ALL RIGHTS RESERVED.
          CREATION DATE: 11/21/84          REVISION DATE: 06/07/95
                           -ADDITIONAL INFORMATION-
THE ABOVE INFORMATION IS BELIEVED TO BE ACCURATE AND REPRESENTS THE BEST
INFORMATION CURRENTLY AVAILABLE TO US. HOWEVER, WE MAKE NO WARRANTY OF
MERCHANTABILITY OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, WITH RESPECT TO
SUCH INFORMATION, AND WE ASSUME NO LIABILITY RESULTING FROM ITS USE. USERS
SHOULD MAKE THEIR OWN INVESTIGATIONS TO DETERMINE THE SUITABILITY OF THE
INFORMATION FOR THEIR PARTICULAR PURPOSES.