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5-MeO-DMT
Timeline
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1936
5-MeO-DMT is first synthesized [Disputed]   

See:

Hoshino, Toshio & Kenya Shimodaira. 1936. "Über die Synthese des Bufotenin-Methyl-Äthers (5-Methoxy-N-Dimethyl-Tryptamin) und Bufotenins. Synthesen in der Indol-Gruppe. XV," Bulletin of the Chemical Society of Japan 11: 221-224.

Stoll, A.; Troxler, F.; Peyer, J.; Hofmann, A. 1955. "Eine neue Synthese von Bufotenin und verwandten Oxytryptamine" in Helvetica Chimica Acta 38: 1452-1472.

and:

Benington, F.; Morin, R.D.; and Leland C. Clark (1958). "Synthesis of O- and N-Methylated Derivatives of 5-Hydroxytryptamine," Journal of Organic Chemistry 23(12): 1977-1979.

and:

Young, J. Chem. Soc. 3493 (1958)



References
Hoshino, Toshio & Kenya Shimodaira. 1936. "Über die Synthese des Bufotenin-Methyl-Äthers (5-Methoxy-N-Dimethyl-Tryptamin) und Bufotenins. Synthesen in der Indol-Gruppe. XV". Bulletin of the Chemical Society of Japan. 11:221-224.
"Smoking Toad". The New York Times Magazine. Jun 5, 1994;48-9.



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