V1.0 March 2004
The short term and long term health impact of 5-MeO-AMT have not been characterized. Its effects are generally similar to AMT, including hallucinations, psychedelic mental effects, sweating, nausea, diarrhea, vomiting, and standard psychedelic-related temporary psychosis problems at high doses.
Acute Health Problems Noted:
Mild hyperthermia has been reported a handful of times and could be a possible problem.
Most of the hospitalization reports we have received have included delusional, dissociated, psychotic behaviour with memory loss for that period.
Treatment of Acute Problems
We have not received detailed reports of how those treated for overdoses of 5-MeO-AMT were treated by the emergency medical personell, but at least one of the hospital reports included fairly standard symptomatic treatment for psychedelic crisis (benzodiazepines and rest).
Contra-indications and Combinations
The pharmacology of 5-MeO-AMT has not been established, but it is likely that it is metabolized by the MonoAmineOxidase enzymes and thus MAO-inhibitors are strongly contra-indicated and could lead to serious medical complications or death if taken together.
It is possible that other recreational stimulants (such as MDMA, 5-MeO-DIPT, or AMT), pharmaceuticals, or supplements might be metabolized through the same pathways or could have unusual, non-linear interactions with 5-MeO-AMT. Those ingesting 5-MeO-AMT should be cautious to avoid being the first to discover a dangerous combination.
Longer Term Issues
Although there are no reports of lasting visual disturbances after taking 5-MeO-AMT, Hallucinogen Persisting Perceptual Disorder has been reported by a small number of people with many visual-altering psychedelics and 5-MeO-AMT could trigger a worsening of symptoms among sufferers of HPPD.
Habituation & Addiction
As of March 2004, it is considered unlikely that 5-MeO-AMT would be habitually used by a measureable portion of the population who tries it. Based on a few hundred anecdotal reports and its similarity in general effects and chemical profile to the other psychedelic-stimulant tryptamines (AMT, 5-MeO-DIPT, etc), serious addiction seems very unlikely to occur. Habitual use seems as if it would have to be reserved for the smallest fringes of experimenters. The combination of strange (and not entirely pleasureable) body effects, long duration (10-16 hours), and mixture of stimulation and distracting peripheral sensations do not seem to suit it to frequent use for many people.