Dose
A common dose of oral 4-Acetoxy-DMT is between 10 and 25 mg. Several reports describe doses of 25-30 mg as very strong, roughly equivalent in effects to 3.5 g of Psilocybe cubensis mushrooms. Insuffalation appears to produce more potent effects with a more rapid onset. A smoked dose of 40 mg of fumurate was described as extremely weak, comparable to the effects of 5 mg oral.

Price
Not commonly available. In July 2007 an Internet vendor listed 4-AcO-DMT at $30 for 100mg, or $130 for 1g.

Law
4-Acetoxy-DMT is unscheduled and uncontrolled in the United States, making it technically legal to possess. Sales or possession could be prosecuted under the Analog Act, although we are not aware of this having occurred. We are not aware of any other country where it is specifically listed as illegal.

Chemistry
4-Acetoxy-N,N-Dimethyltryptamine (4-AcO-DMT) is a synthetic chemical in the tryptamine class. It is related structurally to DMT, 5-MeO-DMT, bufotenine, psilocybin, psilocin, and the neurotransmitter serotonin (5-HT).

Nichols and Frescas write that 4-Acetoxy-DMT "is much more easily prepared than psilocybin, and may offer an economical alternative for clinicians wishing to study the psychopharmacology of psilocin. This material is readily crystallized as the fumarate salt, and is considerably more stable than psilocin itself. It would seem to be an ideal prodrug to replace psilocybin in future clinical studies, since psilocin is the principal metabolite of psilocybin." [ref]

History
4-Acetoxy-DMT is a novel compound with relatively little availability on the research chemicals market. As of 2007, its use appears to primarily be confined to psychedelic connoisseurs.

Slang
Psilacetin

Onset
The onset appears to last 30-40 minutes, with peak effects beginning at around 2 hours. The onset has been characterized as smoother, gentler, and more pleasant than the onset of mushrooms.

Duration
The primary effects of 4-Acetoxy-DMT seem to typically last 4-6 hours. They have been described as lasting from 3-4 hours (low oral doses) to 8-10 hours (moderate to strong oral doses).

The Experience
As with psilocybin, present in magic mushrooms, 4-Acetoxy-DMT is metabolized into psilocin. The effects of 4-Acetoxy-DMT are therefore very similar to the effects of psilocybin and psilocin. Users report dose-dependent colorful visual effects and a sense of physical energy or euphoria, sometimes accompanied by abstract, associative, "trippy" thought patterns, or derealization.

Several available reports of 4-Acetoxy-DMT compare it favorably to psilocybin, describing it as more euphoric, gentle, warm, and colorful. It has also been described as less jarring, and less likely to produce nausea. However, many of these comparisons are made with mushrooms, not pure psilocybin. In addition, it is unknown to what degree expectancy plays a role in shaping that experience.

Addiction Potential
Owing to its pharmacological similarity to psilocybin, it is very unlikely that 4-Acetoxy-DMT is addictive. Howver, it has not been studied for addiction liability.

Contraindications

• Do not operate heavy machinery. Do Not Drive.
  
  
• The effects of smoked 4-Acetoxy-DMT may be dramatically increased if used by individuals currently taking MAOIs. MAOIs are most commonly found in the prescription anti-depressants Nardil (phenelzine), Parnate (tranylcypromine), Marplan (isocarboxazid), Eldepryl (l-deprenyl), and Aurorex or Manerix (moclobemide). Check with your doctor if you are not sure whether your prescription medication is an MAOI.
  
  
• Individuals currently in the midst of emotional or psychological upheaval in their everyday lives should be careful about choosing to use psychedelics as they can trigger even more difficulty.
  
  
• Individuals with a family history of schizophrenia or early onset mental illness should be extremely careful because psychedelics have been known to trigger latent psychological and mental problems.