2C-I
Bits & Pieces
The "Bits & Pieces" section is intended for random snippets of information which don't fit
easily elsewhere and/or which have been newly added, but not yet carefully categorized.
easily elsewhere and/or which have been newly added, but not yet carefully categorized.
- Physostigmine and ChlorpromazineSeveral studies have shown the reversible cholinesterase inhibitor physostigmine to be an effective antidote to BZ intoxication 1,2. This was apparently known to animal pharmacologists well before it became known to medical professionals.
Chlorpormazine (e.g. Thorazine) was explored as a possible antidote by George Aghajanian, but Ketchum reports Aghajanian found that it deepened stupor and delayed recovery 3.
References
1.Crowell EB, Ketchum JS. "The treatment of scopolamine-induced delirium with physostigmine". Clin Pharmacol Ther May-Jun 1967; 8:409-14.2.Duvoisin RC, Katz R. "Reversal of central anticholinergic syndrome in man by physostigmine". JAMA. Nov 25 1968; 206(9):1963-5.
3.Ketchum JS. Chemical Warfare; Secrets Almost Forgotten. James S. Ketchum, MD. 2006.